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EC number: 246-791-8 | CAS number: 25291-17-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 - 24 Aug 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Qualifier:
- according to guideline
- Guideline:
- other: Daphnia sp., Acute immobilization test stipulated in the "Testing Methods for New Chemical Substances" (November 21, 2003; No. 1121002)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: control, 100 mg/L
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The test item was added into the dilution water in an Erlenmeyer flask to produce the 100 mg/L test solution. The flask was immediately sealed with a plug not to produce headspace. The solution was stirred by magnetic stirrer for approx. 48 h. After settling for approx. 1 h at 24 ± 1 °C the middle layer of the settled solution was used for testing. The test vessels were covered immediately with a glass lid not to produce headspace.
- Eluate: no
- Differential loading: yes
- Controls: yes, test medium control
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): No, test solutions were clear and colorless at test start and before renewal. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Source: in-house culture in the laboratory (originally obtained from University of Sheffield, UK)
- Age of parental stock (mean and range, SD): 21 d (young daphnids < 24 h were used for the test)
- Feeding during test: none
ACCLIMATION
- Acclimation conditions (same as test or not): same as test
- Type and amount of food: Chlorella vulgaris (0.1 - 0.2 mg C/day)
- Feeding frequency: once a day
- Health during acclimation (any mortality observed): No mortality was observed. - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 19.9 - 20.0 °C
- pH:
- 7.8 - 7.9
- Dissolved oxygen:
- 8.2 - 8.3 mg/L
- Nominal and measured concentrations:
- nominal: control, 100 mg/L
measured: < LOD, 0.0719 mg/L (geometric mean) - Details on test conditions:
- TEST SYSTEM
- Test vessel: petri dish (diameter: 8 cm, depth: 5 cm)
- Type (delete if not applicable): closed (covered with a petri dish to prevent volatilization of test substance)
- Aeration: no
- Renewal rate of test solution (frequency/flow rate): after 24 h of exposure
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: dechlorinated tap water according to guideline
- Total organic carbon: < 0.1 mg/L
- Chlorine: 15 mg/L (chloride ion)
- Alkalinity: 29 mg/L
- Conductivity: 15.5 mS/m
- Culture medium different from test medium: same as test
- Intervals of water quality measurement: Dissolved oxygen, pH and temperature were measured at test start, before and after renewal and the end of exposure.
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light / 8 h dark
- Light intensity: artificial light of white fluorescent lamp
EFFECT PARAMETERS MEASURED
- Immobility and other symptoms were recorded after 24 and 48 h.
RANGE-FINDING STUDY
- Test concentrations: 100 mg/L
- Results used to determine the conditions for the definitive study: No effects were observed. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.072 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: 0%
- Abnormal responses: No abnormal response was observed. - Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Limit test: no
- Dose-response test: yes
- ECx: EC50 (48 h): 0.296 mg/L (tested in a separate study on 26 - 28 Jun 2007) - Validity criteria fulfilled:
- yes
- Remarks:
- 0% immobilisation in control; O2 content: 8.2 - 8.3 mg/L
- Conclusions:
- EC50 (48 h) > 0.0719 mg/L (geometric mean)
Reference
Table 1: Measured concentrations of the test item in test solutions
Nominal [mg/L] |
Measured concentration [mg/L] |
||||
At test start |
24 h |
At test end |
Geometric mean |
||
Before renewal |
After renewal |
||||
Control |
< LOQ |
< LOQ |
< LOQ |
< LOQ |
- |
100 |
0.0623 |
0.0629 |
0.097 |
0.0704 |
0.0719 |
Description of key information
EC50 (48 h) > 100 mg/L (nominal); > 0.0719 mg/L (meas. (geom. mean))
Key value for chemical safety assessment
Additional information
One experimental study is available investigating the short-term effects of 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene (CAS 25291-17-2) to freshwater invertebrates (Daikin Industries, 2007). The study was performed according to OECD 202 (GLP) using Daphnia magna as test organism. Due to the high vapour pressure of the substance (4640 Pa at 25 °C) it was ensured during preparation of test solutions that the substance does not evaporate from the test medium by avoiding any headspace in the Erlenmeyer flasks and the test vessels. The test solution (limit concentration of 100 mg/L) was prepared by adding an appropriate amount of test substance to dilution water followed by 48 h of stirring and a settling period of 1 h. The middle layer was used for testing. Test solutions were renewed after 24 h. To verify the exposure concentrations analytical measurements using GC/MS were applied. After 48 h no mortality was observed resulting in an EC50 of > 100 mg/L (nominal) and > 0.0719 mg/L (meas. (geom. mean)).
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