Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 243-001-3 | CAS number: 19372-44-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance was assessed in an acute dermal irritation/corrosion test on 6 albino rabbits. The skin was exposed to the test substance for 4 h. Animals were examined for signs of erythema and oedema at 30-60 min, 24, 48 and 72 h post-exposure. No test article-dependent findings were observed. The test substance is not irritating to skin.
A eye irritation/corrosion study was performed. In a single animal 0.1 g of test substance was instilled in the eye. The study was terminated after a hour as severe irritation was apparent. No further details. Since it is not possible to judge the reversibility of these effect and the scores are at the highest level the substance is classified corrosive to the eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 18-21, 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to OECD guideline and GLP. No CoA included in the report.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- 72 hour observation period instead of 14 days
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harald Schriever, Kaninchenfann, D-2740 Bremervorde, Neuendamm 88
- Age at study initiation: no data
- Weight at study initiation: no data
- Housing: individual housing (50 x 45 x 40 em, L x B x H) in a battery of cages, each equipped with a paper roll disposal system.
- Diet (e.g. ad libitum): ad libitum, Ssniff K pellets
- Water (e.g. ad libitum): ad libitum, drinking water as for human consumption
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20±3
- Humidity (%): 30-70
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light):12/12
IN-LIFE DATES: November18-21,1991. - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Remarks:
- The test article was moistened sufficiently with aqua ad iniectabilia.
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 30-6 0min, 24, 48 and 72h after patch removal.
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: back
- % coverage: 6cm2
- Type of wrap if used: Each test area was covered with a semi-occlusive dressing consisting of KosmoplastR (Medilog), which was held in place by non-irritating tape ElastoplastR (BeiersdorfAG, Hamburg), and StiiIpaR (p.HartmannAG, Heidenheim/Brenz), which enveloped the whole of the animal's trunk.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the dressing was removed and any residual sample was carefully washed off with water or an appropriate solvent.
- Time after start of exposure: At the end of the 4-hexposure period.
SCORING SYSTEM:
Erythema and Eschar Formation
0 No erythema
1 Very slight erythema (barely perceptible)
2 Well-defined erythema
3 Moderate to severe erythema
4 Severe erythema (beetredness) to slight eschar formation (injuriesindepth)
Maximum possible = 4
Oedema Formation
0 No oedema
1 Very slight oedema (barely perceptible)
2 Slight oedema (edges of area well defined by definite raising)
3 Moderate oedema (raised approximately 1mm)
4 Severe oedema (raised more than 1mm and extending beyond area of exposure)
Maximumpossible = 4 - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 30-60 min, 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No effects on skin were observed in this study
- Irritant / corrosive response data:
- No test article-dependent findings were observed.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No test article-dependent findings were observed. The test substance is not irritating to skin.
- Executive summary:
The potential toxicity of "Ca-Acetylacetonate" was assessed in an acute dermal irritation/corrosion test on 6 albino rabbits. The skin was exposed to the test substance for 4 h. Animals were examined for signs of erythema and oedema at 30-60 min, 24, 48 and 72 h post-exposure. No test article-dependent findings were observed. The test substance is not irritating to skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 April 1999 - 4 June 1999
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to OECD guideline and GLP. The report is however very concise and does not contain full details on methods and results.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- The report is however very concise and does not contain full details on methods and results.
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Charles River Italia S.p.A.
- Age at study initiation: No data
- Weight at study initiation: No data
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: No data - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye served as the control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 g - Duration of treatment / exposure:
- 1 hour
- Observation period (in vivo):
- 1 hour
- Number of animals or in vitro replicates:
- 1
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
No data
SCORING SYSTEM:
Draize
TOOL USED TO ASSESS SCORE:
No data - Irritation parameter:
- conjunctivae score
- Remarks:
- discharge
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- other: the study was terminated after 1 hour
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: the study was terminated after 1 hour
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- other: the study was terminated after 1 hour
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- other: the study was terminated after 1 hour
- Irritation parameter:
- cornea opacity score
- Remarks:
- opacity
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: the study was terminated after 1 hour
- Irritation parameter:
- cornea opacity score
- Remarks:
- involved area
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: the study was terminated after 1 hour
- Irritant / corrosive response data:
- The study was terminated after a hour as severe irritation was apparent. No further details.
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The study was terminated after a hour as severe irritation was apparent. No further details. Since it is not possible to judge the reversibilty of these effect and the scores at all the highest level the substance is classified corrosive to the eyes.
- Executive summary:
A eye irritation/corrosion study was performed according to OECD guidelines and GLP. In a single animal 0.1 g of test substance was instilled in the eye. The study was terminated after a hour as severe irritation was apparent. No further details. Since it is not possible to judge the reversibility of these effect and the scores are at the highest level the substance is classified corrosive to the eyes.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the available results the substance is not classified for skin irritation/corrosion and corrosive to the eyes, eye damage 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.