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EC number: 237-860-3 | CAS number: 14024-63-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish life cycle toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- materials and methods are well-described
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- lab-designed dose-response test over a long exposure period , spanning life stages from eyed eggs to fish of sexual maturity, and adult fish, respectively
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Details on sampling:
- weekly
- Vehicle:
- no
- Details on test solutions:
- tap water of low hardness
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- tests ran over 22 months total, from "eyed eggs" to fish of sexual maturity. Results after 25 days exposure of adult fish also reported in results and discussion of Sinley et al 1974.
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 22 mo
- Hardness:
- 330 mg/L as CaCO3
- Test temperature:
- 12.7 °C (4.0-18.0 °C)
- pH:
- 6.8
- Dissolved oxygen:
- all tanks were aerated throughout experiment to mainatain adequate dissolved oxygen levels
- Details on test conditions:
- water in aquaria was replaced at a rate of 95% in 20 hours.
- Key result
- Duration:
- 22 mo
- Dose descriptor:
- NOEC
- Effect conc.:
- 140 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mortality
- Key result
- Duration:
- 25 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 25 µg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mortality
- Remarks on result:
- other: calculated from mortality of 8% at 71 µg/l versus 1% at 36 µg/l and 0% in the control group, respectively.
- Details on results:
- results in softwater reported only. results in hardwater are not reported because hardness too high (EU risk assesment 2008).
-for the 22months results, NOEC survival is based on i) mortality of eggs, ii) mortality of yolk-sac fry and iii) mortality of feeding fry and fish. Mortality in feeding fry and fish was 6.9% at 260 µg/l versus 1.4%-2.6% (latter value: control value) at actual concentrations up to 140 µg/l. Eggs and yolk-sac fry were less sensitive. The NOECsurvival (140 µg/l) is in accordance with the view of Sinley et al., 74.
-for the 25 days results, the reported NOEC is calculated from the observed mortality of 8% at 71 µg/l versus 1% at 36 µg/l and 0% in the control group, respectively. Although survival was reduced less than 10% at 71 µg/l, this concentration is considered to be the LOEC and 36 µg/l the NOEC, in accordance with the EU risk assessment (2008) - Reported statistics and error estimates:
- Statistics: p = 0.05
- Validity criteria fulfilled:
- yes
- Conclusions:
- good quality study, NOEC values used for PNEC derivation in the EU risk assessment (ECB 2008)
The NOEC based on dissolved zinc was determined to be 140 µg/L. - Executive summary:
Study on the effect of zinc on rainbow trout in hard and soft water. Tests not done according to standard protocol, but of good quality and considered useful for setting the PNEC freshwater. Study used for that purpose in the EU risk assessment process on zinc (ECB 2008). Culture medium, test water conditions well described and relevant the purpose of PNEC derrivation. NOEC values: see “results” section.
- Endpoint:
- fish life cycle toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- For long-time toxicity a dissociation of bis(pentane-2,4-dionato)zinc can be assumed.
By comparison of all ecotoxicity study resultes of bis(pentane-2,4-dionato)zinc to those of pentane-2,4-dione it can be assumed that the toxicity of the test material is determined only by the zinc moiety. - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- lab-designed dose-response test over a long exposure period , spanning life stages from eyed eggs to fish of sexual maturity, and adult fish, respectively
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Details on sampling:
- weekly
- Vehicle:
- no
- Details on test solutions:
- tap water of low hardness
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- tests ran over 22 months total, from "eyed eggs" to fish of sexual maturity. Results after 25 days exposure of adult fish also reported in results and discussion of Sinley et al 1974.
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 22 mo
- Hardness:
- 330 mg/L as CaCO3
- Test temperature:
- 12.7 °C (4.0-18.0 °C)
- pH:
- 6.8
- Dissolved oxygen:
- all tanks were aerated throughout experiment to mainatain adequate dissolved oxygen levels
- Details on test conditions:
- water in aquaria was replaced at a rate of 95% in 20 hours.
- Key result
- Duration:
- 22 mo
- Dose descriptor:
- NOEC
- Effect conc.:
- 140 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mortality
- Key result
- Duration:
- 22 mo
- Dose descriptor:
- NOEC
- Effect conc.:
- 560 µg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Remarks:
- recalculated for bis(pentane-2,4-dionato)zinc based on the value for dissolved zinc
- Basis for effect:
- mortality
- Details on results:
- results in softwater reported only. results in hardwater are not reported because hardness too high (EU risk assesment 2008).
-for the 22months results, NOEC survival is based on i) mortality of eggs, ii) mortality of yolk-sac fry and iii) mortality of feeding fry and fish. Mortality in feeding fry and fish was 6.9% at 260 µg/l versus 1.4%-2.6% (latter value: control value) at actual concentrations up to 140 µg/l. Eggs and yolk-sac fry were less sensitive. The NOECsurvival (140 µg/l) is in accordance with the view of Sinley et al., 74.
-for the 25 days results, the reported NOEC is calculated from the observed mortality of 8% at 71 µg/l versus 1% at 36 µg/l and 0% in the control group, respectively. Although survival was reduced less than 10% at 71 µg/l, this concentration is considered to be the LOEC and 36 µg/l the NOEC, in accordance with the EU risk assessment (2008) - Reported statistics and error estimates:
- Statistics: p = 0.05
- Validity criteria fulfilled:
- yes
- Conclusions:
- good quality study, NOEC values used for PNEC derivation in the EU risk assessment (ECB 2008)
The NOEC based on dissolved zinc was determined to be 140 µg/L.
The NOEC recalculated for bis(pentane-2,4-dionato)zinc is 263.6 g mol-1 / 65.4 g mol-1 x 140 µg/L = 560 µg/L
Endpoint (NOEC=560ug/L) was taken forward for PNEC derivation. - Executive summary:
Study on the effect of zinc on rainbow trout in hard and soft water. Tests not done according to standard protocol, but of good quality and considered useful for setting the PNEC freshwater. Study used for that purpose in the EU risk assessment process on zinc (ECB 2008). Culture medium, test water conditions well described and relevant the purpose of PNEC derrivation. NOEC values: see “results” section.
Referenceopen allclose all
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 560 µg/L
Additional information
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