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Diss Factsheets
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EC number: 207-622-3 | CAS number: 485-71-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The LD50 of the read across substance quinine sulphate for rats is 455.8 mg/kg bw (350.82 mg quinine/kg bw) after oral application. We conclude that cinchonidine which differs in a methoxy group has a similar LD50 value. The LD50 of cinchonidine after intraperitoneal injection is 206 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: There are no details on the method available.
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- There are no details on the method available.
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 455.8 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no further data
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of the read across substance quinine sulphate for rats is 455.8 mg/kg bw (350.82 mg quinine/kg bw) . We conclude that cinchonidine which differs in a methoxy group has a similar LD50 value.
- Executive summary:
The acute toxicity of the read across substance quinine sulphate was tested on rats after oral application. From the study it is shown, that the LD50 of quinine sulphate is 455.8 mg/kg bw (350.82 mg quinine/kg bw). The read across substance quinine was used to determine the acute toxicity of cinchonidine since cinchonidine differs only in a methoxy group. Furthermore, the LD50 values of cinchonidine and quinine after intraperitoneal injection are similar so that we expect that oral toxicity should be similar, too. Therefore cinchonidine is considered as harmful according to EU criteria and has to be classified in Category 4 according to CLP.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 350.82 mg/kg bw
- Quality of whole database:
- There are no details on the method available.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The acute oral toxicity of the read across substance quinine sulphate was tested on rats. From this study it is shown, that the LD50 of quinine sulphate is 455.8 mg/kg bw (350.82 mg quinine/kg bw). The read across substance quinine was used to determine the acute toxicity of cinchonidine since cinchonidine differs only in a methoxy group. Furthermore, the acute toxicity of cinchonidine was tested via an intraperitoneal injection into six weeks old white rats. The experimental study published by Johnson, 1984 showed that the LD50 of cinchonidine is 206 mg/kg bw. The LD50 values of cinchonidine and quinine after intraperitoneal injection are similar so that we expect, that the oral toxicity should be similar, too.
Justification for classification or non-classification
The LD50 of the read across substance quinine sulphate for rats is 455.8 mg/kg bw (350.82 mg quinine/kg bw) after oral application and the LD50 of cinchonidine for rats after intraperitoneal injection is 206 mg/kg bw. According to CLP 1272/2008 criteria for oral application, LD50 > 300 mg/kg bw and < 2000 mg/kg bw, cinchonidine is considered as harmful, if swallowed and has to be classified in category 4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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