Registration Dossier
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EC number: 205-411-0 | CAS number: 140-31-8
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with Column 2 guidance of REACh Annex IX, testing is not required for substances having low bioaccumulation potential (e.g., log Kow < 3.0). The log Kow of this subsance is -1.48, therefore testing of bioaccumulation is not required.
The substance aminoethyl piperazine is expected to have very low bioaccumulation potential, as the measured log Kow value is -1.48. The measured bioconcentration factor (BCF) for similar substances (piperazine and diethylene triamine) in carp (Cyprinus carpio) were < 6.3 L/kg, supporting this conclusion.
Key value for chemical safety assessment
Additional information
The substance aminoethyl piperazine is expected to have very low bioaccumulation potential, as the measured log Kow value is -1.48. The measured bioconcentration factor (BCF) for similar substances (piperazine and diethylene triamine) in carp (Cyprinus carpio) were < 6.3 L/kg supporting this conclusion.
The results from a study on the bioaccumulation of piperazine(CAS 110-85-0) in Cyprinus carpio (OECD 305C), cited in the EU Risk Assessment Report, support this conclusion. The bioaccumulation was investigated during 42 days at 25°C, in two test concentrations, 0.1 and 1.0 mg piperazine/L. BCF was determined to be 0.9 at the lower concentration, <3.9 at the higher concentration.
The substance diethylene triamine (CAS 111-40-0) was determined to exhibit very low biocentration in freshwater fish (Cyprinus carpio). The measured BCF values ranging from < 0.3 to 6.3 are consistent with such a substance having miscibility in water, low log Kow, and carrying ionic charge(s) under pH conditions encountered in the aquatic environment. The substance is therefore of very low concern for bioaccumulation in aquatic organisms.
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