Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-496-6 | CAS number: 96-29-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The test design is considered robust and the results well documented and scientifically acceptable. The test was not performed according to GLPs.
- Principles of method if other than guideline:
- The hydrolysis of MEKO (at 0.01 M) was examined at pH 4, 7, and 9 and at three different temperatures (20, 35 and 50 °C). Data were collected every day for 5 or 7 days to study the rate of hydrolysis reaction.
- GLP compliance:
- no
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- The hydrolysis of MEKO (at 0.01 M) was examined at pH 4, 7, and 9 and at three different temperatures (20, 35 and 50 °C). Data were collected every day for 5 or 7 days to study the rate of hydrolysis reaction. The concentration of MEKO and one of its hydrolysis products, methylethylketone, were measured by gas chromatography.
- Transformation products:
- not specified
- No.:
- #1
- pH:
- 4
- DT50:
- < 0.3 min
- Type:
- not specified
- Remarks on result:
- other: At this pH, MEKO was hydrolytically unstable regardless of temperature.
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- > 7 d
- Type:
- not specified
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- < 14 d
- Details on results:
- The hydrolysis of MEKO was dependent on pH, but much less dependent of temperature. Detailed results follow:
1) At pH 4, MEKO was hydrolytically unstable, regardless of the temperature (t1/2 < 0.3 minutes).
2) At pH 7, the hydrolysis reaction is much slower; 14% hydrolysis at 20 °C was obtained after 4 days and 44% hydrolysis was obtained at 50 °C after 7 days.
3) At pH 9, no measurable hydrolysis under any of the test conditions was observed. The hydrolysis plateaued at 40-50% by days 4 to 7. The hydrolysis products are methyl ethyl ketone and a hydroxylamine salt. - Conclusions:
- The hydrolysis of MEKO was dependent on pH, but much less dependent of temperature. Detailed results follow: 1) At pH 4, MEKO was hydrolytically unstable, regardless of the temperature (t1/2 < 0.3 minutes). 2) At pH 7, the hydrolysis reaction is much slower; 14% hydrolysis at 20 degrees C was obtained after 4 days and 44% hydrolysis was obtained at 50 degrees C after 7 days. 3) At pH 9, no measurable hydrolysis under any of the test conditions was observed.
Reference
Description of key information
The hydrolysis of MEKO is strongly pH-dependent. At pH 4, MEKO was hydrolytically unstable, regardless of the temperature (t1/2 < 0.3 min). At pH 7, 14% hydrolysis was obtained at 20 °C. Since from the above results no DT50 could be determined at pH7 in the assessment it is assumed that MEKO is not hydrolysable.
Key value for chemical safety assessment
Additional information
The hydrolysis of MEKO (at 0.01 M) was examined at pH 4, 7, and 9 and at three different temperatures (20, 35 and 50 °C) (Honeywell International, Inc., 1988). Data were collected every day for 5 or 7 days to study the rate of hydrolysis reaction. The hydrolysis of MEKO was dependent on pH, but much less dependent on temperature. At pH 4, MEKO was hydrolytically unstable, regardless of the temperature (t1/2 < 0.3 min). At pH 7, the hydrolysis reaction is much slower; 14% hydrolysis at 20 °C was obtained after 4 days and 44% hydrolysis was obtained at 50 °C after 7 days. At pH 9, no measurable hydrolysis under any of the test conditions was observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.