Registration Dossier
Registration Dossier
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EC number: 200-618-2 | CAS number: 65-85-0
Carcinogenicity
Administrative data
Description of key information
A carcinogenicity study with structural analogue sodium benzoate (532-32-1) using rats in diet (Sodemoto, 1979) resulted a NOAEL value of >1000 mg/kg bw/day (2% in food).
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rat
- Quality of whole database:
- 2 (reliable with restrictions)
Justification for classification or non-classification
NOAEL >1000 mg/kg bw/day (2% in food)
Therefore in accordance with Regulation (EC) No. 1272/2008 Tables 3.6.1 the substance is not classified for the carcinogens.
Additional information
A carcinogenicity study with structural analogue sodium benzoate (532-32-1) using rats in diet (Sodemoto, 1979) resulted a NOAEL value of >1000 mg/kg bw/day (2% in food).
Justification for selection of carcinogenicity via oral route endpoint:
Only one read-across study from sodium benzoate available.
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