Summary of Classification and Labelling
Harmonised classification - Annex VI of Regulation (EC) No 1272/2008 (CLP Regulation)
General Information
Index Number EC / List no.

EC: European Community number/ List no.: List number assigned by ECHA.

List Numbers are purely technical identifiers for processing a submission via REACH-IT. More information: https://echa.europa.eu/information-on-chemicals/registered-substances/information

CAS Number International Chemical Identification
615-005-00-9 247-714-0 26447-40-5 methylenediphenyl diisocyanate

ATP Inserted / Updated: CLP00/ATP01 This field indicates when an entry in Annex VI to CLP has been inserted and/or updated with an Adaptation to Technical Progress (ATP) to the CLP Regulation.
CLP Classification (Table 3)
Classification Labelling Specific Concentration limits, M-Factors, Acute Toxicity Estimates (ATE) Notes
Hazard Class and Category Code(s) Hazard Statement Code(s) Hazard Statement Code(s) Supplementary Hazard Statement Code(s) Pictograms, Signal Word Code(s)
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Eye Irrit. 2; H319: C ≥ 5 %
Resp. Sens. 1; H334: C ≥ 0,1 %
STOT SE 3; H335: C ≥ 5 %
Skin Irrit. 2; H315: C ≥ 5 %
Note C
Note 2
Eye Irrit. 2 H319 H319
Skin Sens. 1 H317 H317
Acute Tox. 4 * H332 H332
STOT SE 3 H335 H335
Resp. Sens. 1 H334 H334
Carc. 2 H351 H351
STOT RE 2 * H373 ** H373 **

Signal Words Pictograms
Danger
GHS08
Health hazard
GHS07
Exclamation mark
Seveso III Data
Disclaimer: Please note that some of the substances covered by the Seveso Directive can belong to more than one Seveso categories. It will be up to the users to decide whether their substance or mixture fall in one or in more of these classification categories depending on the tonnage bands and the concentrations.
Please also note that ECHA is not an authority for the Seveso Directive and that the Seveso categorisation below is provided for information only. The Seveso III Directive (Directive 2012/18/EU repealing Directive 96/82/EC (Seveso II) from 1 June 2015) is the only authentic legal reference and that the information in this inventory does not constitute legal advice. For further information on Seveso, please ask your national authority.

Seveso Data
Seveso Substance Seveso Categories
Не
Notified classification and labelling
General Information
EC / List no.

EC: European Community number/ List no.: List number assigned by ECHA.

List Numbers are purely technical identifiers for processing a submission via REACH-IT. More information: https://echa.europa.eu/information-on-chemicals/registered-substances/information

Name CAS Number
The CAS number associated with this substance in the EC Inventory and/or REACH-IT is reported here. In some cases, e.g. for differently hydrated forms of the same substance, alternative CAS numbers have been notified. In those cases, the additional CAS numbers are published in the column “additional notified information” below.
247-714-0 Methylenediphenyl diisocyanate 26447-40-5

Notified classification and labelling according to CLP criteria
Classification Labelling Specific Concentration limits, M-Factors Notes Classification affected by Impurities / Additives

This check appears when a notifier has indicated that an impurity or an additive present in the substance impacts the notified classification. ECHA cannot reveal the identity of the impurity/additive or determine the exact impact it has on the classification.

Additional Notified Information

State/form: The notified state/form of the substance for all notifications classifying in this manner is reported under this link. Additional CAS number(s): Occasionally, a notification contains a different CAS number than the one reported under the general information section above. In those cases, all different notified CAS numbers associated with the aggregated classification are reported under this link. IUPAC name(s): Publicly available IUPAC names from all notifications classifying in this manner are reported under this link.

Number of Notifiers

This number indicates how many companies notified this classification. All members of a REACH registration joint submission and all participants in a group of manufacturers/importers who notified are counted. The grouping is done automatically with no manual verification.

Joint Entries

This check appears when a classification comes from a lead dossier of a REACH registration joint submission. When a member submits a classification separately under Article 11(3) of REACH (opt-out), this classification is displayed separately and not marked as a joint entry.

Hazard Class and Category Code(s) Hazard Statement Code(s) Hazard Statement Code(s) Supplementary Hazard Statement Code(s) Pictograms, Signal Word Code(s)
Skin Irrit. 2 H315 H315 GHS08
GHS06
GHS07
Dgr
Note C
Note 2
355 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 2 H330 H330
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (unknown) H335
Carc. 2 H351 H351
STOT RE 2 H373 (unknown) H373
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Skin Irrit. 2; : C ≥ 5 %
Eye Irrit. 2; : C ≥ 5 %
Note C
Note 2
State/Form
IUPAC Names
175 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 H335
Carc. 2 H351 H351
STOT RE 2 H373 H373
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Eye Irrit. 2; : C ≥ 5 %
Resp. Sens. 1; : C ≥ .1 %
STOT SE 3; : C ≥ 5 %
Skin Irrit. 2; : C ≥ 5 %
State/Form
IUPAC Names
66 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (not available) H335
Carc. 2 H351 H351
STOT RE 2 H373 (not available) H373
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Eye Irrit. 2; : C ≥ 5 %
Skin Irrit. 2; : C ≥ 5 %
STOT SE 3; : C ≥ 5 %
Resp. Sens. 1; : C ≥ .1 %
State/Form
IUPAC Names
59 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 H335
Carc. 2 H351 H351
STOT RE 2 H373 H373
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Resp. Sens. 1; : C ≥ .1 %
Skin Irrit. 2; : C ≥ 5 %
Eye Irrit. 2; : C ≥ 5 %
STOT SE 3; : C ≥ 5 %
Note C
Note 2
State/Form
IUPAC Names
56 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 H335
Carc. 2 H351 H351
STOT RE 2 H373 H373
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
IUPAC Names
45 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
Carc. 2 H351 H351
STOT SE 3 H370 (unknown) H370
STOT RE 2 H373 (unknown) H373
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Eye Irrit. 2; : C ≥ 5 %
Resp. Sens. 1; : C ≥ .1 %
STOT SE 3; : C ≥ 5 %
Skin Irrit. 2; : C ≥ 5 %
State/Form
IUPAC Names
31 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (not specified) H335
Carc. 2 H351  
STOT RE 2 H373 (not specified)  
Not Classified               30  
Skin Irrit. 2 H315 H315 EUH204
GHS08
GHS06
Dgr
30 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 2 H330 H330
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (Not available) H335
Carc. 2 H351 H351
STOT RE 2 H373 (Not available) H373
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Eye Irrit. 2; : C ≥ 5 %
Skin Irrit. 2; : C ≥ 5 %
Resp. Sens. 1; : C ≥ .1 %
STOT SE 3; : C ≥ 5 %
State/Form
29 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (not specified) H335
Carc. 2 H351 H351
STOT RE 2 H373 (not specified)  
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
IUPAC Names 23 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 H335
Carc. 2 H351 H351
STOT RE 2 H373 H373
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
22 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (Affected Organs) H335
STOT RE 2 H373 (Affected Organs) (Inhalation) H373
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Eye Irrit. 2; : C ≥ 5 %
STOT SE 3; : C ≥ 5 %
Resp. Sens. 1; : C ≥ .1 %
Skin Irrit. 2; : C ≥ 5 %
State/Form
IUPAC Names
18 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (lungs) H335
Carc. 2 H351 H351
STOT RE 2 H373 (Lung) (Inhalation) H373
Skin Irrit. 2 H315 H315 EUH204
Dgr
State/Form
IUPAC Names
12 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (lungs) (Inhalation) H335
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
IUPAC Names 10 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (respiratory tra...) H335
Carc. 2 H351 H351
STOT RE 2 H373 (respiratory tra...) H373
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Resp. Sens. 1; : C ≥ .1 %
Eye Irrit. 2; : C ≥ 5 %
STOT SE 3; : C ≥ 5 %
Skin Irrit. 2; : C ≥ 5 %
Note C
Note 2
6 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (Respiratory sys...) H335
Carc. 2 H351 H351
STOT RE 2 H373 (Lungs) H373
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
IUPAC Names
6 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (not identified) H335
Carc. 2 H351 H351
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Skin Irrit. 2; : C ≥ 5 %
STOT SE 3; : C ≥ 5 %
Resp. Sens. 1; : C ≥ .1 %
Eye Irrit. 2; : C ≥ 5 %
State/Form
5 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (Respiratory sys...) H335
Carc. 2 H351 H351
STOT RE 2 H373 (not specified)  
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Skin Irrit. 2; : 5 % ≤ C < 100 %
Resp. Sens. 1; : .1 % ≤ C < 100 %
Eye Irrit. 2; : 5 % ≤ C < 100 %
Note C
Note 2
4 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
Carc. 2 H351 H351 (Suspected of ca...)
STOT RE 2 H373 (respiratory sys...) H373 (May cause damag...)
Skin Irrit. 2 H315 H315 (H315) GHS08
GHS07
Dgr
Note C
Note 2
IUPAC Names 4 View details
Skin Sens. 1 H317 H317 (H317)
Eye Irrit. 2 H319 H319 (H319)
Acute Tox. 4 H332 H332 (H332)
Resp. Sens. 1 H334 H334 (H334)
STOT SE 3 H335 (respiratory sys...) H335 (H335)
Carc. 2 H351 H351 (H351)
STOT RE 2 H373 (eyes, skin, res...) H373 (H373)
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
STOT SE 3; : C ≥ 5 %
Eye Irrit. 2; : C ≥ 5 %
Resp. Sens. 1; : C ≥ .1 %
Skin Irrit. 2; : C ≥ 5 %
Note C
Note 2
3 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (Upper respirato...) H335
Carc. 2 H351 H351
STOT RE 2 H373 (Upper respirato...) H373
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Eye Irrit. 2; : 5 % ≤ C < 100 %
Resp. Sens. 1; : .1 % ≤ C < 100 %
STOT SE 3; : 5 % ≤ C < 100 %
Skin Irrit. 2; : 5 % ≤ C < 100 %
Note C
Note 2
3 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (Not applicable) H335
Carc. 2 H351 H351 (Suspected of ca...)
STOT RE 2 H373 (respiratory sys...) H373 (May cause damag...)
Acute Tox. 4 H302   GHS08
GHS07
Dgr
State/Form
2 View details
Skin Irrit. 2 H315 H315
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (Lung) H335
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Skin Irrit. 2; : C ≥ 5 %
Resp. Sens. 1; : C ≥ .1 %
Eye Irrit. 2; : C ≥ 5 %
Note C
1 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
  H335
Skin Irrit. 2 H315 H315 Dgr
1 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (not specified) H335
Carc. 2 H351 H351
STOT RE 2 H373 (not specified) H373
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Eye Irrit. 2; : 5 % < C ≤ 100 %
Resp. Sens. 1; : .1 % < C ≤ 100 %
Skin Irrit. 2; : 5 % < C ≤ 100 %
Note C
Note 2
1 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
Carc. 2 H351 H351 (Suspected of ca...)
STOT RE 2 H373 (respiratory sys...) H373 (May cause damag...)
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
1 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (data lacking) H335
Carc. 2 H351 H351
STOT RE 2 H373 (data lacking) H373
Skin Irrit. 2 H315 H315 GHS08
GHS07
Wng
Note C
Note 2
State/Form
1 View details
Skin Sens. 1 H317 H317
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 2 H335 (not determined) H335
Carc. 2 H351 (dermal and inha...) H351
STOT RE 2 H373 (not determined) H373

Number of Aggregated Notifications: 28