Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: N-methylaniline
  • IUPAC name: N-methylaniline
  • Other names
EC / List no.:
202-870-9
CAS no.:
100-61-8
Index number:
612-015-00-5
Molecular formula:
C7H9N
SMILES:
CNC1=CC=CC=C1
InChI:
InChI=1S/C7H9N/c1-8-7-5-3-2-4-6-7/h2-6,8H,1H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
8
Of which contain:
4 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is toxic if swallowed, is toxic in contact with skin, is toxic if inhaled, is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects and may cause damage to organs through prolonged or repeated exposure.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance causes damage to organs, causes serious eye irritation, is a flammable liquid and vapour, is suspected of causing genetic defects, is suspected of causing cancer and may cause respiratory irritation.

Breakdown of all 286 C&L notifications submitted to ECHA

Acute Tox. 3 H301 Harmonised Classification
Acute Tox. 3 H331 Harmonised Classification
Aquatic Acute 1 H400 Harmonised Classification
STOT RE 2 H373 Harmonised Classification
Acute Tox. 3 H311 Harmonised Classification
Aquatic Chronic 1 H410 Harmonised Classification
Eye Irrit. 2 H319
Eye Irrit. 2A H319
STOT SE 1 H370
STOT RE 1 H372
Flam. Liq. 4 H226
Acute Tox. 4 H302
Muta. 2 H341
Carc. 2 H351
STOT SE 2 H371
https://echa.europa.eu/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 7 active registrations under REACH, 2 Joint Submission(s) and 2 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 - 1 000 tonnes per year.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: fuels.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers and in materials as fuel sources, with limited exposure to unburned product to be expected.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and manufacturing of the substance.

This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, laboratory work and in materials as fuel sources, with limited exposure to unburned product to be expected.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates) and of substances in closed systems with minimal release.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance and formulation of mixtures.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not breathe the dust, fume, gas, mist, vapours or spray; use only outdoors or in a well-ventilated area; do not get in eyes, on skin, or on clothing; do not eat, drink or smoke when using this product; use personal protective equipment as required.; avoid release to the environment; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray; in case of inadequate ventilation wear respiratory protection.

Response statements

In case of incident: Call a poison center or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. If in contact with eyes, remove contact lenses if present and easy to do - continue rinsing. Get medical advice/attention if you feel unwell. If swallowed: immediately call a poison center or doctor/physician. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. Collect spillage. Rinse the mouth. If eye irritation persists get medical advice/attention. Call a poison center or doctor/physician. Remove/take off immediately all contaminated clothing. If on skin: wash with soap and water. Follow specific treatment (see label).

Storage statements

Store this substance locked up; in a well-ventilated place and keeping container tightly closed.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • ACS DOBFAR S.p.A, Viale Addetta 4/12 20067 Tribiano Milano Italy
  • ALCHEMIE INDUSTRIES CHEMICAL SPAIN, S.L., Atlantida, 21 1º3º 08930 Sant Adria de Besos Spain
  • CHIMEC S.p.A., Via delle Ande 19 00144 Roma Italy
  • China System S.r.L., Via Dei Volsci 163 00185 Rome Italy
  • Connect Chemicals Italia S.r.l., Via Torri Bianche, 9 20871 Vimercate (MB) Italy
  • Haltermann Carless UK Limited, Grove House Guildford Road KT22 9DF Leatherhead Surrey United Kingdom
  • Synthesia, a.s., Semtín103 53002 Pardubice Czech Republic
  • SC Rompetrol Rafinare SA, Navodari Street no.215, Administrative Building 905700 Navodari Constanta Romania

Other names

  • -
  • Benzenamine, N-methyl-
  • N-Methyaniline
  • N-methyl-N-phenylamine N-methylaniline
  • N-METHYLANILINE
  • N-METHYLANILINE-
  • (Methylamino)benzene
  • Benzenamine, N-methyl-
  • Benzenenamine
  • methylaniline-n
  • Methylphenylamine
  • MONOMETHYLANILINE
  • n-methyl-anilin
  • n-methyl-benzenamin
  • N-methylaniline
  • N-Methylanilinium ion
  • N-Methylbenzenamine
  • N-MONOMETHYLANILINE
  • n’-BIcthylanilin

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 4 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [2]
C Form
Other (100%) [2]
C Odour
Ammonia-like (100%) [2]
C Substance type
Organic (100%) [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4
Other
Data waiving
no waivers
C Summaries
  • 5 summaries submitted
  • 5 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 6 studies submitted
  • 2 studies processed
R Melting / freezing point
-57 °C [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 4
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 5 summaries processed
Melting / freezing point at 101 325 Pa
-57 °C

Boiling point

Study results
  • 8 studies submitted
  • 6 studies processed
R Boiling point
194 - 196 °C @ 101.325 kPa [6]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 2 4
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 5 summaries processed
Boiling point at 101 325 Pa
196 - 196.25 °C

Density

Study results
  • 6 studies submitted
  • 4 studies processed
R Density
0.989 g/cm³ @ 20 °C [2]
R Relative density
0.99 [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 6
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 5 summaries processed
Relative density at 20°C
0.986 - 0.989

Vapour pressure

Study results
  • 6 studies submitted
  • 4 studies processed
R Vapour pressure
60.395 - 133 Pa @ 36 °C [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 4
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 5 summaries processed
Vapour pressure
40 - 60.4 Pa @ 25 °C

Partition coefficient

Study results
  • 6 studies submitted
  • 4 studies processed
R Log Pow
1.66 - 1.7 [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 4
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 5 summaries processed
Log Kow (Log Pow)
1.66 @ 20 °C

Water solubility

Study results
  • 6 studies submitted
  • 4 studies processed
R Water solubility (mass/vol.)
5.6 - 5.62 g/L [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 4
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 5 summaries processed
Water solubility
5.6 - 5.624 g/L @ 20 - 25 °C

Solubility in organic solvents / fat solubility

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 2
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 6 studies submitted
  • 4 studies processed
R Flash point
79.4 - 79.5 °C [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 4
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 5 summaries processed
Flash point at 101 325 Pa
78 - 79.5 °C

Auto flammability

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Autoflammability / self-ignition at 101 325 Pa
490 °C

Flammability

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Flammability
Flammable (67%), Non flammable (33%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 4 studies submitted
  • 4 studies processed
C Dissociating properties
Not determined (100%) [4]
R Dissociation constant
4.848 - 4.85 @ 25 °C [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 2
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 4 summaries processed
pKa at 20 °C
4.848

Viscosity

Study results
  • 2 studies submitted
  • 2 studies processed
R Other:
1.766 - 2.568 [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 6 studies submitted
  • 2 studies processed
C Interpretation of results
Inherently biodegradable (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Inherently biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 6 2
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation Factor (BCF) - L/kg ww
10 L/kg ww

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Henrys law constant (H)

Study results
  • 2 studies submitted
  • 2 studies processed
R H - (pressure) m³/mol
0.9 - 1.16 Pa m³/mol [6]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 3 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 2.1 µg/L (2)
Intermittent releases (freshwater) 1.74 µg/L (2)
Marine water 210 ng/L (2)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 150 µg/L (2)
Sediment (freshwater) 10 µg/kg sediment dw (2)
Sediment (marine water) 1 µg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 7.6 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning 167 µg/kg food (2)

Short–term toxicity to fish

Study results
  • 6 studies submitted
  • 4 studies processed
P/RResults
LC50 (48 h) 38 - 91.2 mg/L [10]
LC50 (24 h) 50 mg/L [2]

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence 4
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
38 mg/L

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (4 days) 0.2 µmol/L [2]
LC50 (4 days) 0.71 µmol/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 6 studies submitted
  • 4 studies processed
P/RResults
LC50 (48 h) 174 - 5 600 µg/L [4]

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence 4
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
174 µg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 290 µg/L [2]
EC50 (21 days) 590 µg/L [2]

Type of Study provided
Studies with data
Key study
Supporting study 4
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 4 studies submitted
  • 4 studies processed
P/RResults
EC50 (4 days) 44 - 138 mg/L [8]
EC50 (72 h) 3.8 mg/L [2]
NOEC (72 h) 140 - 320 µg/L [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 2
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
20.4 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
EC50 (3 h) 3.74 mg/L [2]
EC50 (30 min) 1.5 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 49.5 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 22 mg/m³ repeated dose toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 41.7 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 7 mg/kg bw/day repeated dose toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 36.9 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 6.2 mg/m³ repeated dose toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 20.8 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 3.5 mg/kg bw/day repeated dose toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 10.4 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 2.1 mg/kg bw/day acute toxicity
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence 6 4
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential

Acute toxicity

Study results
oral
  • 4 studies submitted
  • 2 studies processed
P/RResults
LD50 716 - 782 mg/kg bw (rat) [4]
LD0 512 mg/kg bw (rat) [2]
M/CInterpretations of results
Category 4 based on GHS criteria [2]

Type of Study provided
oral
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
dermal
  • 4 studies submitted
  • 2 studies processed
P/RResults
LD100 3 000 mg/kg bw (rabbit) [2]
M/CInterpretations of results
Other [2]

dermal
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
other routes
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 280 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence 2 2
Other
Data waiving
no waivers
Study data: eye
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEL (rat): 5 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 10 studies submitted
  • 2 studies processed
P/RResults
LOAEC (rat): 13.3 mg/m³ air [2]

Study data: inhalation
Studies with data
Key study 2
Supporting study 4 4
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 2
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed LOAEL 5 mg/kg bw/day (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 4
Supporting study
Weight of evidence 10
Other
Data waiving
no waivers
Study data: in vivo
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Study data: developmental
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study
Supporting study 2
Weight of evidence 2
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant