Registration Dossier
Registration Dossier
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EC number: 256-367-4 | CAS number: 49553-76-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects to fish up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
Since no studies investigating the short-term toxicity to fish of Oleic acid, monoester with oxybis(propandiol) (CAS 49553-76-6) are available for this endpoint, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to a structurally similar analogue substance 2,3-dihydroxypropyl oleate (CAS 111-03-5) was conducted. This read-across is justified in detail in the overall summary (IUCLID chapter 6.1) and within the analogue justification in IUCLID Section 13. For the endpoints short-term toxicity to aquatic invertebrates and toxicity to algae, both substances are showing a consistent pattern of results Therefore, a similar hazard assessment is expected for both substances for all other endpoints.
The study with 2,3-dihydroxypropyl oleate (CAS 111-03-5) was performed according to OECD 203 under GLP conditions (MOE, 2001). Oryzias latipes was exposed to six measured concentrations (geometric mean) between 0.55 and 102.8 mg/L in a semi-static test for 96 h. No effects were observed resulting in an LC50 > 102.8 mg/L.
Based on the results from a structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) ,characterized by a similar ecotoxicological profile, it can be concluded that Oleic acid, monoester with oxybis(propandiol) will not exhibit short-term effects to fish up to the limit of water solubility.
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